App knock-in mouse strains: new models for Alzheimer’s disease C57BL/6-App/TcsRbrc (RBRC06342) C57BL/6-App/TcsRbrc (RBRC06343) C57BL/6-App/TcsRbrc (RBRC06344) Courtesy of Takaomi C. Saido, Ph.D. and Takashi Saito, Ph.D. App knock-in mice exhibit AD patient-like Aβ42-dominant plaque deposition concomitantly with neuroinflammation … A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Mutation discovered to protect against Alzheimer’s disease in mice, 2-1 Hirosawa, Wako, Saitama 351-0198, JapanEmail: saido [at] brain.riken.jp. β1,3-N-acetylglucosaminyltransferase 2 (β3GnT2) is a polylactosamine synthase that synthesizes a backbone structure of carbohydrate structures onto glycoproteins.Here we generated β3GnT2-deficient (β3GnT2 −/−) mice and showed that polylactosamine on N-glycans was markedly reduced in their immunological tissues.In WT mice, polylactosamine was present on CD28 and CD19, … Laboratory Head: Takaomi Saido (Ph.D.) Japanese Page; ... Takashi Saito Deputy Laboratory Head. Hiroki Sasaguri Research Scientist. C57BL/6 background. RIKEN, Japan. Developed by Takashi Saito and Takaomi C. Saido, RIKEN Brain Science Institute in 2009. PMID: 31160584 Electronic address: takashi.saito@riken.jp. takashi.saito.aa@riken.jp. Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako-shi, Saitama, Japan. Now, a research team led by Takaomi Saido from the RIKEN Brain Science Institute in Wako has identified a particular fragment of the amyloid precursor protein ... “Aβ 43 could also be a diagnostic marker for Alzheimer's disease,” explains Takashi Saito, the first author of the study. Because these processes are relatively down-stream to Aβ deposition in the disease cascade, we expect the outcome to contribute to AD research in therapeutic rather than preventive terms. C57BL/6 derived ES cells were used to generate the mutant mice. Dynamic 11 C-GW2580- and 11 C-CPPC-PET images were quantified by reference tissue … Takashi Saito 1 Affiliation 1 Laboratory for Cell Signaling, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. Takayuki Imanishi 1 , Midori Unno 2 , Wakana Kobayashi 2 , Natsumi Yoneda 2 , Shizuo Akira 3 , Takashi Saito 4 Affiliations 1 Laboratory for Cell Signaling, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Kanagawa 230-0045, Japan. C57BL/6 derived ES cells were used to generate the mutant mice. Career: 21-15, 84 SV, 2.34 ERA, 400 SO, P, AllStar, Dodgers/RedSox/... 2006-2012, t:R, born in Japan 1970, Sammy PMID: 32698010 DOI: 10.1016/j.celrep.2020.107911 Abstract Effector, but not naïve, T cells are activated by toll-like receptor-2 (TLR2) stimulation, leading to cytokine production and proliferation. Colony-stimulating factor 1 receptor (CSF1R) is a specific biomarker for microglia. Proteolytic reactions often play critical roles in both physiological and pathological circumstances because of their irreversible nature, but their actual in vivo functions particularly in brain are not yet well understood. RIKEN Center for Integrative Medical Sciences Laboratory for Cell Signaling Team Leader: Takashi Saito (Ph.D.) Research overview and publication list - Takaomi Saido, Proteolytic Neuroscience, RIKEN Center for Brain Science (RIKEN CBS) Jun. Strain description Naoyuki Taniguchi Osaka Univeristy and RIKEN and Osaka International Cancer Institute 確認したメール アドレス: ... Takashi Saito. RIKEN Center for Brain Science Laboratory for Proteolytic Neuroscience. Research overview and publication list - Takaomi Saido, Proteolytic Neuroscience, RIKEN Center for Brain Science (RIKEN CBS) By elucidating the mechanism of Aβ metabolism, we intend to establish a new approach to prevent AD development by reducing Aβ burdens in aging brains. Strain description Affiliated With. RIKEN Center for Integrative Medical Sciences, Adaptor protein inhibits T-cell activation, Laboratory for Cell Signaling | RIKEN RCAI, Gender Equality and Promotion of Diversity, RIKEN Center for Advanced Intelligence Project (AIP), RIKEN Center for Advanced Photonics (RAP), RIKEN Center for Biosystems Dynamics Research (BDR), RIKEN Center for Emergent Matter Science (CEMS), RIKEN Interdisciplinary Theoretical and Mathematical Sciences Program (iTHEMS), RIKEN Center for Integrative Medical Sciences (IMS), RIKEN Nishina Center for Accelerator-Based Science (RNC), RIKEN Center for Sustainable Resource Science (CSRS), RIKEN Center for Computational Science (R-CCS), RIKEN Cluster for Pioneering Research (CPR), RIKEN Cluster for Science, Technology and Innovation Hub (RCSTI), RIKEN Program for Drug Discovery and Medical Technology Platforms (DMP), RIKEN Industrial Co-creation Program (ICoP), RIKEN Preventive Medicine & Diagnosis Innovation Program (PMI), Head Office for Information Systems and Cybersecurity (ISC). All rights reserved. (8)Laboratory for Cell Signaling, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan. The aim of our research is to understand the mechanism of brain aging with specific emphasis on the study Alzheimer's disease (AD) through proteolysis. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. Copyright © RIKEN, Japan. A floxed neo cassette was removed by crossing with EIIa-cre mice (B6.FVB-Tg(EIIa-cre)C5379Lmgd/J). University of Palermo, Italy. 4, 2019 Cases by Outcome. Closing in on cancerous clusters, May 30, 2014 A floxed neo cassette was removed by crossing with EIIa-cre mice (B6.FVB-Tg(EIIa-cre)C5379Lmgd/J). Takashi Saito. Team Leader: Ken-ichi Masuda (Ph.D.) Deputy Team Leader: Takashi Saito (Ph.D.) Japanese Page; Research Summary. Abstract. A floxed neo cassette was removed by crossing with EIIa-cre mice (B6.FVB-Tg(EIIa-cre)C5379Lmgd/J). Naomasa Kakiya Research Scientist. takashi.saito.aa@riken.jp. These include the regulation of immunological synapse, T cell receptor-induced signal transduction, co-stimulation regulation and signaling in T cell development. Emails: takashi.saito.aa@riken.jp, takaomi.saido@riken.jp This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Signal transduction through TCR upon antigen recognition 7615) Fax: +81‐48‐467‐9716. “We would now like to develop it along these lines.” Now a team of researchers, led by Takashi Saito from the RIKEN Research Center for Allergy and Immunology in Yokohama, has given clear insights into the way constituent parts of the immune system communicate with each other. Copyright © RIKEN, Japan. Kenichi Nagata 1 , Takashi Saito 2 , Takaomi C Saido 3 , Takashi Morihara 4 Affiliations 1 Department of Precision Medicine for Dementia, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan; Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Saitama, Japan. Kenichi Nagata Research Scientist. Takashi Saito was born in Tokyo, Japan, in 1950. Alzheimer’s disease protein links plaques to cell death in mice, Mutation discovered to protect against Alzheimer’s disease in mice, Laboratory for Proteolytic Neuroscience | RIKEN Center for Brain Science, Gender Equality and Promotion of Diversity, RIKEN Center for Advanced Intelligence Project (AIP), RIKEN Center for Advanced Photonics (RAP), RIKEN Center for Biosystems Dynamics Research (BDR), RIKEN Center for Emergent Matter Science (CEMS), RIKEN Interdisciplinary Theoretical and Mathematical Sciences Program (iTHEMS), RIKEN Center for Integrative Medical Sciences (IMS), RIKEN Nishina Center for Accelerator-Based Science (RNC), RIKEN Center for Sustainable Resource Science (CSRS), RIKEN Center for Computational Science (R-CCS), RIKEN Cluster for Pioneering Research (CPR), RIKEN Cluster for Science, Technology and Innovation Hub (RCSTI), RIKEN Program for Drug Discovery and Medical Technology Platforms (DMP), RIKEN Industrial Co-creation Program (ICoP), RIKEN Preventive Medicine & Diagnosis Innovation Program (PMI), Head Office for Information Systems and Cybersecurity (ISC). Takashi Saito (斎藤 隆, Saitō Takashi), born February 14, 1970, is a retired Japanese professional baseball pitcher who last played for the Tohoku Rakuten Golden Eagles of Nippon Professional Baseball. (9)Cell Signaling, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan. Please enable JavaScript in your browser. C57BL/6 derived ES cells were used to generate the mutant mice. Analytics. All rights reserved. takashi.saito.aa@riken.jp. For this purpose, we generated 2nd generation mouse models of AD, which overproduce Aβ42 without overexpressing amyloid precursor protein. Naoyuki Taniguchi Osaka Univeristy and RIKEN and Osaka International Cancer Institute 確認したメール アドレス: ... Takashi Saito. Among the various aspects of protease involvement in neuropathophysiology, our research focuses on two major themes. Vaccination is the effective method as protection from pathogenic infection and prevention of severe symptoms, which has been widely used. A floxed neo cassette was removed by crossing with EIIa-cre mice (B6.FVB-Tg(EIIa-cre)C5379Lmgd/J). takashi.saito@riken.jp. Alzheimer’s disease protein links plaques to cell death in mice, May 4, 2018 Developed by Takashi Saito and Takaomi C. Saido, RIKEN Brain Science Institute in 2009. Takashi Saito 2, Nobuhisa Iwata 2, 3, Takaomi C Saido 2, Miyako Nakano 4, Yoshiki Yamaguchi 5, Yasuhiro Hashimoto 6, Matthias Staufenbiel 7, Hiroyuki Hatsuta 8, Shigeo Murayama 8, Hiroshi Manya 9, Tamao Endo 9 and ; Naoyuki Taniguchi 1; 1 Disease Glycomics Team, RIKEN‐Max Planck Joint Research Center, Global Research Cluster, RIKEN, Wako, Japan Cases by Type In spermatogonial stem cells (SSCs), Myc controls SSC fate decisions because Myc overexpression induces enhanced self-renewal division, while depletion of Max, a Myc-binding partner, leads to meiotic induction.However, the mechanism by which Myc acts on SSC fate is unclear. Team Leader: Ken-ichi Masuda (Ph.D.) Deputy Team Leader: Takashi Saito (Ph.D.) Japanese Page; Research Summary. Emails: takashi.saito.aa@riken.jp, takaomi.saido@riken.jp. RIKEN Baton Zone Program Vaccine Innovation Laboratory. Tel: +81‐48‐462‐1111 (Ext. Emails: takashi.saito.aa@riken.jp, takaomi.saido@riken.jp. Vaccination is the effective method as protection from pathogenic infection and prevention of severe symptoms, which has been widely used. In cortical regions of brains from individuals with preclinical or clinical Alzheimer’s disease (AD), extracellular amyloid-β (Aβ) deposition precedes the aggregation of pathological intracellular tau (the product of the gene microtubule-associated protein tau [MAPT]).To our knowledge, current mouse models of tauopathy reconstitute tau pathology by overexpressing mutant … Takashi Saito. (2)Laboratory for Cell Signaling, RIKEN Center for Integrative Medical Sciences., 1 7 22 Suehiro-cho, Yokohama, 230 0045, Japan. Beat A. Imhof. (8)Laboratory for Cell Signaling, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan. Fox Chase Cancer Center, United States. C57BL/6 background. 8 Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Nagoya-City, Aichi, 464-8601, Japan. Group Director：Takashi Saito Immune response is triggered upon antigen recognition by T cells through T cell receptor (TCR), and the activated T cells exhibit cell proliferation (clonal expansion) and functional differentiation, and effector function. Giuliana Guggino. Abstract. 19, 2019 He graduated from the Tokyo Institute of Technology in 1975. These models will also be useful for the search of biomarkers. Dying cells trigger immunity, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa, 230-0045, Japan Tel: +81-(0)45-503-7037 Fax: +81-(0)45-503-7036Email: takashi.saito [at] riken.jp. RIKEN Baton Zone Program Vaccine Innovation Laboratory. The editor and reviewers' affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review. 7 Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako-City, Saitama, 351-0198, Japan. Shoko Hashimoto Developed by Takashi Saito and Takaomi C. Saido, RIKEN Brain Science Institute in 2009. One is the metabolism of amyloid-βpeptide (Aβ), the cortical deposition of which triggers the pathological cascade leading to AD. Apr. Takashi Saito and Takaomi C. Saido, Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, 2‐1 Hirosawa, Wako‐city, Saitama 351‐0198, Japan. Reviewed by Motonari Kondo. Since 2004 Saito has been a group director at Laboratory for Cell Signaling of RIKEN Center for Integrative Medical Sciences. C57BL/6 derived ES cells were used to generate the mutant mice. The general goal of this laboratory is to elucidate the mechanism of activation, differentiation and function, and its regulation of T cells which play central roles in the regulation of immune responses and homeostasis. In this study, we developed a novel PET radioligand for CSF1R, 11 C-GW2580, and compared it to a reported CSF1R tracer, 11 C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey. C57BL/6 background. In 1988, Takashi took a position of an assistant professor at Chiba University. takashi.saito@riken.jp. (7)Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako-City, Saitama, 351-0198, Japan. Shoko Hashimoto, 1 Yukio Matsuba, 1 Naoko Kamano, 1 Naomi Mihira, 1 Naruhiko Sahara, 2 Jiro Takano, 1 Shin-ichi Muramatsu, 3, 4 Takaomi C. Saido, 1 and Takashi Saito 1, 5 Shoko Hashimoto 1 Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, 2 … C57BL/6 derived ES cells were used to generate the mutant mice. T cell antigen receptor (TCR) stimulation induces recruitment and accumulation of various types of signaling molecules and forms signaling microclusters. takashi.saito@riken.jp. Reviewed by David L. Wiest. Takashi Saito, Yukio Matsuba, Naomi … The other objective is to define the roles of intracellular proteases, calpains and caspases, and also of autophagy in the processes of neuronal dysfunction and degeneration in AD and other neurodegenerative diseases. Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako-shi, Saitama, Japan. Leydig Voit & Mayer, Ltd. 700 THIRTEENTH STREET, NW SUITE 300 WASHINGTON, D 20005 Phone: +1 301 571 0052. Developed by Takashi Saito and Takaomi C. Saido, RIKEN Brain Science Institute in 2009. Tel: +81‐48‐462‐1111 (Ext. Toho University, Japan. Under physiological conditions, Aβ is constantly produced from its precursor and immediately catabolized, whereas dysmetabolism of Aβ seems to lead to pathological deposition upon aging. Also he worked as a professor at the same university from 1989 to 2004. We also aim to identify the mechanisms (pathways), by which Aβ amyloidosis causes tauopathy and neurodegeneration. Please enable JavaScript in your browser. Since 2004 Saito has been a group director at Laboratory for Cell Signaling of RIKEN Center for Integrative Medical Sciences. takashi.saito@riken.jp. Search for more papers by this author Strain description Now, a research team led by Takaomi Saido from the RIKEN Brain Science Institute in Wako has identified a particular fragment of the amyloid precursor protein ... “Aβ 43 could also be a diagnostic marker for Alzheimer's disease,” explains Takashi Saito, the first author of the study. Also he worked as a professor at the same university from 1989 to 2004. The editor and reviewers' affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review. Search for more papers by this author 7615) Fax: +81‐48‐467‐9716. takashi.saito.aa@riken.jp. Université de Genève, Switzerland. 1Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako-city, Saitama 351-0198, Japan takashi.saito.aa@riken.jp. (8)Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Nagoya-City, Aichi, 464-8601, Japan. Adaptor protein inhibits T-cell activation, Apr. Takashi Saito, Yukio Matsuba, Naomi … Myc plays critical roles in the self-renewal division of various stem cell types. Particularly, the mechanism to induce autoimmune diseases and inflammations caused by aberrant regulation of T cell function and activation will be analyzed to aim to overcome the diseases. Keiro Shirotani 1 2 , Yuma Hori 3 4 , Ryohei Yoshizaki 3 , Eri Higuchi 3 , Marco Colonna 5 , Takashi Saito 6 , Shoko Hashimoto 7 , Takashi Saito 7 , Takaomi C Saido 7 , Nobuhisa Iwata 8 9 Affiliations A floxed neo cassette was removed by crossing with EIIa-cre mice (B6.FVB-Tg(EIIa-cre)C5379Lmgd/J). Loop is the open research network that increases the discoverability and impact of researchers and their work. Developed by Takashi Saito and Takaomi C. Saido, RIKEN Brain Science Institute in 2009. When the RIKEN Research Center for Allergy and Immunology was established in 2001, he was assigned as a group director of the Laboratory for Cell Signaling. 10, 2015 In 1988, Takashi took a position of an assistant professor at Chiba University. Affiliations. In 2004, he became Deputy Director of the center. Takashi Saito Deputy Director at RIKEN Research Center for Allergy and Immunology 日本 神奈川県 横浜市 研究開発 Takashi Saito and Takaomi C. Saido, Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, 2‐1 Hirosawa, Wako‐city, Saitama 351‐0198, Japan. Takashi Saito Curriculun Vitae CONTACT: Address; 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan Tel: +81-45-503-7037(Group Director) +81-45-503-7024 & 7038(Secretary) Fax: +81-45-503-7036 E-mail: saito@rcai.riken.jp “We would now like to develop it along these lines.” Affiliations. RIKEN, Japan. 2Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Aichi 464-8601, Japan. (9)Cell Signaling, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan. , RIKEN Center for Integrative Medical Sciences, Immunology Frontier Research Center, Osaka 565-0871, Japan Department of and!, our Research focuses on two major themes the mechanisms ( pathways ), by which amyloidosis. Masuda ( Ph.D. ) Japanese Page ; Research Summary ( EIIa-cre ) C5379Lmgd/J ) mice B6.FVB-Tg! 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